Keywords: Tablet hardness/effects. Granule size. Lubricant concentration. Polymer. INTRODUCTION Granule sizes play an important role in obtaining the hardness of tablets. Generally, as granules size increased, tablets were found to show increased weight variation, decreased hardness and increased friability. Whereas in
Pharmaceutical dosage forms as a vehicle to deliver the drug to the site of absorption. Solid dosage forms as a matrix system
Tablet friability problem
In British Pharmacopeia,the dissolution test for tablets or capsules is based on the rotating paddle system.Tablets or capsules are placed in a basket of wire mesh,the mesh is being small enough to retain broken pieces of tablet but large enough to allow entry of solvent without wetting problems.The basket may be rotated at any suitable aped,but most monographs specify 50,100 or 1500 rpm.But ...
1.18 Evaluation of Tablet 14 1.18.1 Weight variationtest of tablets 14-15 184.108.40.206 How to overcome the weight variation of tablets 16-17 1.18.2 Tablet Friability 17 220.127.116.11 Acceptable range of friability 18 18.104.22.168 Purpose of friability 18 22.214.171.124 Possible causes of friability problems 18
tablet hardness tester (Monsanto Hardness Tester)[10,11]. 2.6.1 Friability: Ten tablets were weighed and placed in a Roche friabilator and the equipment was rotated at 25 rpm for 4 min. The tablets were taken out, dedusted and reweighed. The percentage friability of the tablets was measured[10,11].